News

Paper of the Month (November 2017)

08 Dec 2017

Kategaya L., Di Lello P., Rougé L., Pastor R., Clark K.R., Drummond J., et al. (2017) USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature, 550: 534.

https://www.nature.com/articles/nature24006

Paper of the Month (Oct 2017)

01 Nov 2017

Lasko L.M., Jakob C.G., Edalji R.P., Qiu W., Montgomery D., Digiammarino E.L., et al. (2017) Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature550(7674): 128-132. 

http://www.nature.com/nature/journal/v550/n7674/full/nature24028.html

Paper of the Month (Aug 2017)

02 Oct 2017

Jiang H., Deng R., Yang X.,  SHang J., Lu S., Zhao Y., Song K., Liu X., Zhang Q., Chen E., Wu G., Li J., Chen G., Yu J. & Zhang J. (2017) Peptidomimetic Inhibitors of APC-Asef interaction block colorectal cancer migration.  Nat. Chem. Biol. 13, 994-1001 

http://www.nature.com/nchembio/journal/v13/n9/full/nchembio.2442.html?foxtrotcallback=true

Paper of the Month (July 2017)

10 Jul 2017

Grison C.M., Burslem G.M., Miles J.A., Pilsl L.K.A., Yeo D.J., Imani Z., Warriner S.L., Webb M.E. & Wilson A.J. (2017) Double quick, double click reversible peptide “stapling”. Chem. Sci., 8(7): p. 5166-5171.

http://pubs.rsc.org/en/Content/ArticleLanding/2017/SC/C7SC01342F#!divAbstract

 

Paper of the Month (June 2017)

14 Jun 2017

 McCoull, W., Abrams, RD., Anderson, E., Blades, K., Barton, P. et al. (2017) Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. Journal of Medicinal Chemistry 60 (10), 4386-4402

http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.7b00359