News

Paper of the Month (June 2017)

14 Jun 2017

 McCoull, W., Abrams, RD., Anderson, E., Blades, K., Barton, P. et al. (2017) Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. Journal of Medicinal Chemistry 60 (10), 4386-4402

http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.7b00359

 

Paper of the Month (May 2017)

07 Jun 2017

 Niu, X., Brahmbhatt, H., Mergenthaler, P., Zhang, Z., Sang, J., Daude, M., Ehlert, F. G. R., Diederich, W. E., Wong, E., Zhu, W., Pogmore, J., Nandy, J. P., Satyanarayana, M., Jimmidi, R. K., Arya, P., Leber, B., Lin, J., Culmsee, C., Yi, J. & Andrews, D. W. (2017) A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chemical Biology 24, 493-506.e495

http://www.sciencedirect.com/science/article/pii/S2451945617300946

 

4th Young Researchers Symposium (2017)

02 May 2017

PPI-Net Young Researchers Symposium

University of Leeds, 19th September 2017

Plenary Lectures

Michelle Arkin- University of California, San Francisco

Luc Brunsveld- Eindhoven University of Technology

Following the success of last years international conference at the SCI in London, The Protein-Protein Interactions Network (PPI-Net, www.ppi-net.org) are excited to announce the 4th Young Researchers Symposium on PPIs, at the University of Leeds to be held 19th of September. This symposium aims to provide a platform for early career researchers from a broad range of backgrounds to come together, share their work and discuss the latest research on PPIs and their inhibition. In addition to our excellent guest speakers there will also be opportunities for young researchers to present their work through talks and posters chosen from abstracts so please submit yours when you register.  Registration is Free.  

Registration in advance at www.poppi.website or click here

Abstract submission deadline 20th July

If you have any questions, please contact us at s.martin1@leeds.ac.uk

Paper of the Month (April 2017)

02 May 2017

 

Berlow, R. B., Dyson, H. J. & Wright, P. E. (2017) Hypersensitive termination of the hypoxic response by a disordered protein switch. Nature 543, 447-451 

https://www.nature.com/nature/journal/v543/n7645/full/nature21705.html

Paper of the Month (March 2017)

10 Apr 2017

 

Kumar, S., Hamilton, A. D., (2017) Alpha-Helix Mimetics as Modulators of Alpha-Beta Self-Assembly, J. Am. Chem. Soc. (in press)

http://pubs.acs.org/doi/abs/10.1021/jacs.6b09734