Paper of the Month (December 2016)

11 Jan 2017

Happy New Year to all PPI-Net members, here is the belated December's paper of the month

Spencer-Smith et al. (2017). Inhibition of RAS function through targeting an allosteric regulatory site. Nature Chemical Biology 13, 62-68 .


Paper of the Month (October 2016)

02 Nov 2016

October's paper of the month

Kotchy et al. (2016). The Mcl-1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature 538, 477-482.



Paper of the Month (September 2016)

12 Oct 2016

September's paper of the month

Akcay, G., M. A. Belmonte, B. Aquila, C. Chuaqui, A. W. Hird, M. L. Lamb, P. B. Rawlins, N. Su, S. Tentarelli, N. P. Grimster and Q. Su (2016). "Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain." Nat Chem Biol advance online publication.

Paper of the Month (August 2016)

03 Oct 2016

Sorry belated paper of the month for August.

Sable, R., Durek, T., Taneja, V., Craik, D. J., Pallerla, S., Gauthier, T., and Jois, S. Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein–Protein Interaction,

ACS Chem. Biol. 2016, 11, 2366-2374

Transfer of Ownership

14 Jun 2016

Ownership of PPI-Net has been transferred to the EPSRC Programme Grant being led by Prof. Andy Wilson, University of Leeds. 

As part of this transfer, the website will be updated in due course.