Paper of the Month

10 Mar 2014

Srinivasan, P.; Yasgar, A.; Luci, D. K.; Beatty, W. L.; Hu, X.; Andersen, J.; Narum, D. L.; Moch, J. K.; Sun, H.; Haynes, J. D.; Maloney, D. J.; Jadhav, A.; Simeonov, A.; Miller, L. H. Nat Commun 2013, 4. Disrupting malaria parasite AMA1–RON2interaction with a small molecule prevents erythrocyte invasion.

End of Funding

12 Nov 2013

The Research Council’s funding for PPI-net formally comes to an end in November 2013; we would like to thank all members of the community for engaging with the project and making it such a huge success. It is clear that there is strong enthusiasm from the community to continue to sustain and evolve this network going forward. Despite the conclusion of research council support for the initiative, we have secured a small amount of funding in order to continue some PPI-net activities until we make a formal proposal to the Research Councils for further support.

As well as these monies, we have also established a small molecule compound library (selected for PPIs) for the community. This is stored in Leeds and is intended to assist the community by making copies available free of charge as a starting point for screens and assays.  GSK have also generously contributed £10,000 towards further expansion of the library. Further information on what the library comprises and how to access it will follow soon.

Paper of the month

25 Sep 2013

Kim, W., G. H. Bird, et al. (2013). Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 9(10): 643-650.

Placement Award

23 Jul 2013

A Placement has been awarded to

Ali Tavassoli (University of Southampton)

Pump-Priming Placement Award

10 Jul 2013

1 Pump-Priming  Placement has been awarded to:

Andy Wilson (University of Leeds) and Darren Tomlinson (University of Leeds)