Free PPI-Net compound library
11 Sep 2014
PPI-Net is delighted to announce that a compound collection that was purchased using PPI-Net funds is now available for free of charge (except for postage) to all PPI-Net members. This PPI Net compound collection is a library of 1534 compounds that can be used for screening.
This is stored in Leeds and is intended to assist the community by making copies available free of charge as a starting point for screens and assays. GSK have also generously contributed £10,000 towards further expansion of the library.
PPI-Net members can request access to the request sytem in order to view the SD files and order compounds by emailing us.
3rd Young Researchers Symposium
11 Apr 2014
The PPI-Net Young Researchers Symposium has taken place on the 7th April 2014 at Imperial College London
Congratulations to the winners of the prizes that were presented by Professor Geoff Barton from the University of Dundee:
Diana Monteiro (University of Leeds) “Structural studies of pantothenase biosynthesis”
Colin Robinson (Institute of Cancer Research) for the poster entitled “Small Molecule Probes for Protein-Protein Interactions: Mimicking Beta-Sheet Motifs”
and Sozan Qarani (University of Nottingham) for the poster entitled “Investigating the role of the non-integrin laminin receptor in the pathogenesis of meningococcal meningitis”
Paper of the Month
10 Mar 2014
Srinivasan, P.; Yasgar, A.; Luci, D. K.; Beatty, W. L.; Hu, X.; Andersen, J.; Narum, D. L.; Moch, J. K.; Sun, H.; Haynes, J. D.; Maloney, D. J.; Jadhav, A.; Simeonov, A.; Miller, L. H. Nat Commun 2013, 4. Disrupting malaria parasite AMA1–RON2interaction with a small molecule prevents erythrocyte invasion.
End of Funding
12 Nov 2013
The Research Council’s funding for PPI-net formally comes to an end in November 2013; we would like to thank all members of the community for engaging with the project and making it such a huge success. It is clear that there is strong enthusiasm from the community to continue to sustain and evolve this network going forward. Despite the conclusion of research council support for the initiative, we have secured a small amount of funding in order to continue some PPI-net activities until we make a formal proposal to the Research Councils for further support.
As well as these monies, we have also established a small molecule compound library (selected for PPIs) for the community. This is stored in Leeds and is intended to assist the community by making copies available free of charge as a starting point for screens and assays. GSK have also generously contributed £10,000 towards further expansion of the library. Further information on what the library comprises and how to access it will follow soon.
Paper of the month
25 Sep 2013
Kim, W., G. H. Bird, et al. (2013). Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 9(10): 643-650.