Bartling, C. R. O., Jensen, T.M.T., Henry, S.M., Colliander, A.L., Sereikaite, V. et al. (2021) Targeting the APP-Mint2 Protein–Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation. JACS. https://doi.org/10.1021/jacs.0c10696
Amy Rees
Paper of the Month – December
Słabicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S.S. et al. (2020) Small-molecule-induced polymerization triggers degradation of BCL6. Nature 588, 164–168 https://doi.org/10.1038/s41586-020-2925-1
Paper of the Month – November
Henley, M. J., Linhares, B.M., Morgan, B.S., Cierpicki, T., Fierke, C.A. & Mapp, A.K. (2020) Unexpected specificity within dynamic transcriptional protein–protein complexes. PNAS 117, 27346-27353, doi:10.1073/pnas.2013244117
Paper of the Month – October
Wolter, M., Valenti, D., Cossar, P.J., Levy, L.M., Hristeva, S., et al. (2020) Fragment‐Based Stabilizers of Protein-Protein Interactions through Imine‐Based Tethering. Angew. Chem. Int. Ed., doi:10.1002/anie.202008585
Paper of the Month – August
Curran P.R., Radoux C.J., Smilova M.D., Sykes R.A., Higueruelo A.P., et al. (2020) Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design. J. Chem. Inf. Model., 60, 4, 1911–1916 https://pubs.acs.org/doi/10.1021/acs.jcim.9b00996
Paper of the Month June
Bosc N., Muller C., Hoffer L., Lagorce D., Bourg S., et al. (2020) Fr-PPIChem: An Academic Compound Library Dedicated to Protein–Protein Interactions. ACS Chem. Biol., https://doi.org/10.1021/acschembio.0c00179
Paper of the Month – April
Sadek J., Wuo M.G., Rooklin D., Hauenstein A., Hong S.H. et al. (2020) Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics. Nat. Commun., 11, 1786 https://doi.org/10.1038/s41467-020-15576-3
Paper of the Month – March
Guéret S.M., Thavam S., Carbajo R.J., Potowski M., Larsson N., et al. (2020) Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments. J. Am. Chem. Soc., 142, 4904-4915 https://pubs.acs.org/doi/pdf/10.1021/jacs.0c00269
Paper of the Month – February
Testa A., Hughes S. J., Wright J. E., Ciulli A. (2020) Structure-Based Design of a Macrocyclic PROTAC. Angew. Chem. Int. Ed., 59, 1727-1734 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914396
Paper of the Month – January
O’Connell J., Porter J., Kroeplien B., Norman T., Rapecki S., et al. (2019) Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nature Commun., 10, 5795 https://doi.org/10.1038/s41467-019-13616-1