Amy Rees

Bartling, C. R. O., Jensen, T.M.T., Henry, S.M., Colliander, A.L., Sereikaite, V. et al. (2021) Targeting the APP-Mint2 Protein–Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation. JACS. https://doi.org/10.1021/jacs.0c10696

Słabicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S.S. et al. (2020) Small-molecule-induced polymerization triggers degradation of BCL6. Nature 588, 164–168 https://doi.org/10.1038/s41586-020-2925-1

Henley, M. J., Linhares, B.M., Morgan, B.S., Cierpicki, T., Fierke, C.A. & Mapp, A.K. (2020) Unexpected specificity within dynamic transcriptional protein–protein complexes. PNAS 117, 27346-27353, doi:10.1073/pnas.2013244117

Wolter, M., Valenti, D., Cossar, P.J., Levy, L.M., Hristeva, S., et al. (2020) Fragment‐Based Stabilizers of Protein-Protein Interactions through Imine‐Based Tethering. Angew. Chem. Int. Ed., doi:10.1002/anie.202008585

Curran P.R., Radoux C.J., Smilova M.D., Sykes R.A., Higueruelo A.P., et al. (2020) Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design. J. Chem. Inf. Model., 60, 4, 1911–1916 https://pubs.acs.org/doi/10.1021/acs.jcim.9b00996

Bosc N., Muller C., Hoffer L., Lagorce D., Bourg S., et al. (2020) Fr-PPIChem: An Academic Compound Library Dedicated to Protein–Protein Interactions. ACS Chem. Biol., https://doi.org/10.1021/acschembio.0c00179

Sadek J., Wuo M.G., Rooklin D., Hauenstein A., Hong S.H. et al. (2020) Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics. Nat. Commun., 11, 1786 https://doi.org/10.1038/s41467-020-15576-3

Guéret S.M., Thavam S., Carbajo R.J., Potowski M., Larsson N., et al. (2020) Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments. J. Am. Chem. Soc., 142, 4904-4915 https://pubs.acs.org/doi/pdf/10.1021/jacs.0c00269

Testa A., Hughes S. J., Wright J. E., Ciulli A. (2020) Structure-Based Design of a Macrocyclic PROTAC. Angew. Chem. Int. Ed., 59, 1727-1734 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914396

O’Connell J., Porter J., Kroeplien B., Norman T., Rapecki S., et al. (2019) Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nature Commun., 10, 5795 https://doi.org/10.1038/s41467-019-13616-1