denawh – Protein-Protein Interactions Network

Paper of the Month – July

17th July 201917th July 2019 by denawh

Achala, N. D., Hewage, P., Yao, H., Nammalwar, B., Gnanasekaran, K.K., et al. (2019) Small Molecule Inhibitors of the BfrB–Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity. J. Am. Chem. Soc. 141: https://pubs.acs.org/doi/10.1021/jacs.9b00394

Paper of the Month – June

19th June 201919th June 2019 by denawh

Miles, J. A., Hobor, F., Taylor, J., Tiede, C., Rowell, P.R., Trinh, C. H., Jackson, B., Nadat, F., Kyle, H. F., Wicky, B. I. M., Clarke, J., Tomlinson, D. C., Wilson, A. J., Edwards, T. A. et al. (2019) Selective Affirmers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs. BioRxiv 651364; doi: 10.1101/651364 https://www.biorxiv.org/content/10.1101/651364v1

Paper of the Month – May

22nd May 2019 by denawh

Frappier, V., Jenson, J. M., Zhou, J., Grigoryan, G., Keating, A. E. (2019) Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure 27: 606-617.e5 https://doi.org/10.1016/j.str.2019.01.008

Paper of the Month – April

7th May 2019 by denawh

Wu, Q., Heidenreich, D., Zhou, S., Ackloo, S., Krämer, A., Nakka, K., et al. (2019) A chemical toolbox for the study of bromodomains and epigenetic signaling. Nature Commun. 10: 1915 https://doi.org/10.1038/s41467-019-09672-2

Paper of the Month – January

18th January 201918th January 2019 by denawh

Cao Q., Shin W. S., Chan H., Vuong C. K., Dubois B., et al. (2018) Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat. Chem. 10, 1213-1221 https://doi.org/10.1038/s41557-018-0147-z

Paper of the Month – December

11th December 201811th December 2018 by denawh

Burslem, G. M., Song, J., Chen, X., Hines, J. & Crews, C. M. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J. Am. Chem. Soc. 140, 16428-16432, (2018).

https://doi.org/10.1021/jacs.8b10320

Protein-Protein Interactions 2019

27th November 201827th November 2018 by denawh

We are pleased to announce that the next Protein-Protein Interactions Conference will take place on Thursday 4 – Friday 5 April 2019 at the University of Leeds, UK.

The call for abstracts is now open with a deadline of Friday 11 January 2019. Contributions are encouraged from all scientists working on the understanding or manipulation of protein-protein interactions, including PhD students and early career researchers.

Registration will be open shortly.

Download a copy of the flyer here: PPI 2019 A5 FLYER