Guéret S.M., Thavam S., Carbajo R.J., Potowski M., Larsson N., et al. (2020) Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments. J. Am. Chem. Soc., 142, 4904-4915 https://pubs.acs.org/doi/pdf/10.1021/jacs.0c00269
Paper of the Month – February
Testa A., Hughes S. J., Wright J. E., Ciulli A. (2020) Structure-Based Design of a Macrocyclic PROTAC. Angew. Chem. Int. Ed., 59, 1727-1734 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914396
Paper of the Month – January
O’Connell J., Porter J., Kroeplien B., Norman T., Rapecki S., et al. (2019) Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nature Commun., 10, 5795 https://doi.org/10.1038/s41467-019-13616-1
Paper of the Month – December
Jeganathan S., Wendt M., Kiehstaller S., Brancaccio D., Kuepper A., et al. (2019) Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly. Angew. Chem. Int. Ed. 58, 17351-17358 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201907901
Paper of the Month – July
Achala, N. D., Hewage, P., Yao, H., Nammalwar, B., Gnanasekaran, K.K., et al. (2019) Small Molecule Inhibitors of the BfrB–Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity. J. Am. Chem. Soc. 141: https://pubs.acs.org/doi/10.1021/jacs.9b00394
Paper of the Month – June
Miles, J. A., Hobor, F., Taylor, J., Tiede, C., Rowell, P.R., Trinh, C. H., Jackson, B., Nadat, F., Kyle, H. F., Wicky, B. I. M., Clarke, J., Tomlinson, D. C., Wilson, A. J., Edwards, T. A. et al. (2019) Selective Affirmers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs. BioRxiv 651364; doi: 10.1101/651364 https://www.biorxiv.org/content/10.1101/651364v1
Paper of the Month – May
Frappier, V., Jenson, J. M., Zhou, J., Grigoryan, G., Keating, A. E. (2019) Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure 27: 606-617.e5 https://doi.org/10.1016/j.str.2019.01.008
Paper of the Month – April
Wu, Q., Heidenreich, D., Zhou, S., Ackloo, S., Krämer, A., Nakka, K., et al. (2019) A chemical toolbox for the study of bromodomains and epigenetic signaling. Nature Commun. 10: 1915 https://doi.org/10.1038/s41467-019-09672-2
Paper of the Month – January
Cao Q., Shin W. S., Chan H., Vuong C. K., Dubois B., et al. (2018) Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat. Chem. 10, 1213-1221 https://doi.org/10.1038/s41557-018-0147-z
Paper of the Month – December
Burslem, G. M., Song, J., Chen, X., Hines, J. & Crews, C. M. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J. Am. Chem. Soc. 140, 16428-16432, (2018).