Achala, N. D., Hewage, P., Yao, H., Nammalwar, B., Gnanasekaran, K.K., et al. (2019) Small Molecule Inhibitors of the BfrB–Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity. J. Am. Chem. Soc. 141: https://pubs.acs.org/doi/10.1021/jacs.9b00394
Paper of the Month – June
Miles, J. A., Hobor, F., Taylor, J., Tiede, C., Rowell, P.R., Trinh, C. H., Jackson, B., Nadat, F., Kyle, H. F., Wicky, B. I. M., Clarke, J., Tomlinson, D. C., Wilson, A. J., Edwards, T. A. et al. (2019) Selective Affirmers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs. BioRxiv 651364; doi: 10.1101/651364 https://www.biorxiv.org/content/10.1101/651364v1
Paper of the Month – May
Frappier, V., Jenson, J. M., Zhou, J., Grigoryan, G., Keating, A. E. (2019) Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure 27: 606-617.e5 https://doi.org/10.1016/j.str.2019.01.008
Paper of the Month – April
Wu, Q., Heidenreich, D., Zhou, S., Ackloo, S., Krämer, A., Nakka, K., et al. (2019) A chemical toolbox for the study of bromodomains and epigenetic signaling. Nature Commun. 10: 1915 https://doi.org/10.1038/s41467-019-09672-2
Paper of the Month – January
Cao Q., Shin W. S., Chan H., Vuong C. K., Dubois B., et al. (2018) Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat. Chem. 10, 1213-1221 https://doi.org/10.1038/s41557-018-0147-z
Paper of the Month – December
Burslem, G. M., Song, J., Chen, X., Hines, J. & Crews, C. M. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J. Am. Chem. Soc. 140, 16428-16432, (2018).
Protein-Protein Interactions 2019
We are pleased to announce that the next Protein-Protein Interactions Conference will take place on Thursday 4 – Friday 5 April 2019 at the University of Leeds, UK.
The call for abstracts is now open with a deadline of Friday 11 January 2019. Contributions are encouraged from all scientists working on the understanding or manipulation of protein-protein interactions, including PhD students and early career researchers.
Registration will be open shortly.
Download a copy of the flyer here: PPI 2019 A5 FLYER
Paper of the Month – November
Rogers J. M., Passioura T. & Suga H. (2018) Nonproteinogenic deep mutational scanning of linear and cyclic peptides. Proc. Natl. Acad. Sci. U. S. A. 115: 10959-10964http://www.pnas.org/content/pnas/115/43/10959
Transfer of Ownership
Ownership of PPI-Net has been transferred to the EPSRC Programme Grant being led by Prof. Andy Wilson, University of Leeds.