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Paper of the Month – August

11th August 2020 by Amy Rees

Curran P.R., Radoux C.J., Smilova M.D., Sykes R.A., Higueruelo A.P., et al. (2020) Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design. J. Chem. Inf. Model., 60, 4, 1911–1916 https://pubs.acs.org/doi/10.1021/acs.jcim.9b00996

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Paper of the Month June

3rd June 2020 by Amy Rees

Bosc N., Muller C., Hoffer L., Lagorce D., Bourg S., et al. (2020) Fr-PPIChem: An Academic Compound Library Dedicated to Protein–Protein Interactions. ACS Chem. Biol., https://doi.org/10.1021/acschembio.0c00179

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Paper of the Month – April

30th April 2020 by Amy Rees

Sadek J., Wuo M.G., Rooklin D., Hauenstein A., Hong S.H. et al. (2020) Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics. Nat. Commun., 11, 1786 https://doi.org/10.1038/s41467-020-15576-3

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Paper of the Month – March

24th March 202024th March 2020 by Amy Rees

Guéret S.M., Thavam S., Carbajo R.J., Potowski M., Larsson N., et al. (2020) Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments. J. Am. Chem. Soc., 142, 4904-4915 https://pubs.acs.org/doi/pdf/10.1021/jacs.0c00269

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Paper of the Month – February

21st February 2020 by Amy Rees

Testa A., Hughes S. J., Wright J. E., Ciulli A. (2020) Structure-Based Design of a Macrocyclic PROTAC. Angew. Chem. Int. Ed., 59, 1727-1734 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914396

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Paper of the Month – January

17th January 2020 by Amy Rees

O’Connell J., Porter J., Kroeplien B., Norman T., Rapecki S., et al. (2019) Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nature Commun., 10, 5795 https://doi.org/10.1038/s41467-019-13616-1

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Paper of the Month – December

11th December 2019 by Amy Rees

Jeganathan S., Wendt M., Kiehstaller S., Brancaccio D., Kuepper A., et al. (2019) Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly. Angew. Chem. Int. Ed. 58, 17351-17358 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201907901

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Paper of the Month – July

17th July 2019 by Amy Rees
Achala, N. D., Hewage, P., Yao, H., Nammalwar, B., Gnanasekaran, K.K., et al. (2019) Small Molecule Inhibitors of the BfrB–Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity. J. Am. Chem. Soc. 141: https://pubs.acs.org/doi/10.1021/jacs.9b00394
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Paper of the Month – June

19th June 2019 by Amy Rees

Miles, J. A., Hobor, F., Taylor, J., Tiede, C., Rowell, P.R., Trinh, C. H., Jackson, B., Nadat, F., Kyle, H. F., Wicky, B. I. M., Clarke, J., Tomlinson, D. C., Wilson, A. J., Edwards, T. A. et al. (2019) Selective Affirmers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs. BioRxiv 651364; doi: 10.1101/651364 https://www.biorxiv.org/content/10.1101/651364v1

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Paper of the Month – May

22nd May 2019 by Amy Rees

Frappier, V., Jenson, J. M.,  Zhou, J., Grigoryan, G.,  Keating, A. E. (2019) Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure 27: 606-617.e5 https://doi.org/10.1016/j.str.2019.01.008

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