Frappier, V., Jenson, J. M., Zhou, J., Grigoryan, G., Keating, A. E. (2019) Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure 27: 606-617.e5 https://doi.org/10.1016/j.str.2019.01.008
Wu, Q., Heidenreich, D., Zhou, S., Ackloo, S., Krämer, A., Nakka, K., et al. (2019) A chemical toolbox for the study of bromodomains and epigenetic signaling. Nature Commun. 10: 1915 https://doi.org/10.1038/s41467-019-09672-2
Cao Q., Shin W. S., Chan H., Vuong C. K., Dubois B., et al. (2018) Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat. Chem. 10, 1213-1221 https://doi.org/10.1038/s41557-018-0147-z
Burslem, G. M., Song, J., Chen, X., Hines, J. & Crews, C. M. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J. Am. Chem. Soc. 140, 16428-16432, (2018).
We are pleased to announce that the next Protein-Protein Interactions Conference will take place on Thursday 4 – Friday 5 April 2019 at the University of Leeds, UK.
The call for abstracts is now open with a deadline of Friday 11 January 2019. Contributions are encouraged from all scientists working on the understanding or manipulation of protein-protein interactions, including PhD students and early career researchers.
Registration will be open shortly.
Download a copy of the flyer here: PPI 2019 A5 FLYER
Rogers J. M., Passioura T. & Suga H. (2018) Nonproteinogenic deep mutational scanning of linear and cyclic peptides. Proc. Natl. Acad. Sci. U. S. A. 115: 10959-10964http://www.pnas.org/content/pnas/115/43/10959
Ownership of PPI-Net has been transferred to the EPSRC Programme Grant being led by Prof. Andy Wilson, University of Leeds.
The PPI-Net Young Researchers Symposium has taken place on 13th September at Leeds University. The aim of the symposium was to provide a platform for early career researchers from a broad range of backgrounds to come together, share their work and discuss the latest research on PPIs and their inhibition. Michelle Arkin of the University of California, San Francisco, and Luc Brunsveld of the Eindhoven University of Technology both delivered excellent Plenary lectures.
Congratulations to the winners of the prizes!
Rachel Everett, University of Oxford
Valeria Azzarito, University of Leeds
Chris Douse, Imperial College London
Pitch for Placement:
Vidya Pawar, Oxford Brookes University
The PPI-Net Young Researchers Symposium has taken place on the 7th April 2014 at Imperial College London
Congratulations to the winners of the prizes that were presented by Professor Geoff Barton from the University of Dundee:
Diana Monteiro (University of Leeds) “Structural studies of pantothenase biosynthesis”